Study of Serum Soluble Cell Adhesion Molecules Relation with Severity of Multiple Sclerosis Different Groups

Abstract

Background: Multiple sclerosis (MS) is a chronic and autoimmune disease of the central nervous system (CNS), The McDonald diagnostic criteria allow an earlier and often more accurate diagnosis of  MS to be made by utilizing MRI.

Aim: The purpose of this study was to find correlation between serum level of  soluble cell adhesion molecules and  the clinical severity assessment using Expanded  Disability status Scale  and  Magnetic Resonance Imaging findings in patients with Multiple Sclerosis disease.

Subjects and Methods: :  Our study included 32 patients with clinically definite multiple sclerosis  patients and consisted of (18 patients with Relapsing Remittent MS (3 males &15 females), 4 males with Primary Progressive MS and 10 females with secondary progressive MS) who met the criteria of clinically definite MS according to revised McDonald criteria 2017, selected from Neurology Department, Zagazig University Hospitals  and Outpatient Clinic. Also 32 age and sex matched healthy volunteers as control group were included in this study. History taking, clinical evaluation of disease severity by the  Expanded Disability Status Scale (EDSS), as well as adhesion molecules which was measured in serum, were done to all subjects.

Results: Regarding differences between Multiple Sclerosis patients’ subgroups, it was found that, sNCAM level was statistically significant increase in PPMS and SPMS groups compared to RRMS group while in sVCAM there was a statistical significance increase in PPMS and SPMS groups compared to RRMS group and also in SPAM compared to PPSM group. Finally, in sICAM, there was astatistical significant increase in SPMS groups compared to RRMS and PPMS groups.

Conclusion: we can assess serum level of soluble adhesion molecules to find the association between their serum levels & clinical assessment and Magnetic Resonance Imaging  findings of disease severity in Multiple Sclerosis  patients.