The Effect of Different Level of Flaxseed Oil on Biochemical Changes on Hypercholesterolemic Rats

Abstract

       Flaxseed oil has beneficial effects on many chronic diseases in human and animals. Besides, flaxseed oil has also received increasing attention for its potential role in preventing lipid disorders. However, some studies have shown that whole flaxseed oil lower serum cholesterol in animal and human. so  we worked This study to determine the effect of different level of flaxseed oil on biochemical changes on hypercholesterolemic rats. The study used (24) white Albino rats and were divided into two main groups first set of mice infected with hypercholesterolemic, Second Group of negative control, a non-mice group infected and was then the first and second main group is divided into four sub-groups, including two groups fed with different concentrations of (20% and 25%) flaxseed oil and one group control positive infected with the disease do not feed on the experimental diet and another control negative non-infected this disease means that all mice are divided into four groups of six mice in each group. The result showed that non significant differences in HDL levels between 20%  ,25% flaxseed oil and control negative when compared with control positive Also, there were significant decreases in ALP between the groups replaced with different percentage of flaxseed oil compared with control (+) group . The results suggests to use different levels of flaxseed oil for hypercholesterolmic patients , also  suggests  future studies may be to evaluate the efficacy and advantage of using  flaxseed oil as extracts.