Physiologic Outcome after using Home Non-Invasive Positive Pressure Ventilation in Chronic Respiratory Failure Patients

Abstract

Background: Non-invasive positive pressure ventilation (NIPPV) is an e effective long-term treatment for chronic respiratory failure, Home NPPV has been shown to reduce patient’s symptoms, improve physiologic measurements as   health-related quality of life (HRQOL), PaCO2, PaO2, FEV1, FVC and  6 Minute walk test.

Aim of the current work was to monitor patients on Home NPPV as a long-term treatment for   chronic respiratory failure stressing on their outcome, quality of life, ABG, Spiro metric PFT and 6MWT.

Methods: All Patients in this  study 48 were  either  known or newly diagnosed chronic respiratory failure who were  newly advised Home NPPV as a long term treatment according to the accepted guidelines for the initiation of NIV in different patient groups  according to recommendations of the Swiss Society of Pulmonology 2020 for long-Term Mechanical Ventilation, the modality of NIV was CPAP or a bilevel positive pressure device in a spontaneous/timed mode delivered  with fixed levels of positive end-expiratory pressure and pressure support and a backup respiratory rate). Inspiratory and expiratory positive airway pressures (IPAP and EPAP) were adjusted according to the patient’s comfort, synchrony with the ventilator, marked reduction in the use of accessory muscles and accepted blood gases analysis.

Results: Patients included were 26 males (54.1%) and 22 females (45.9%) with a mean ± SD age 52.94 ± 13.39 years. Mean ± SD of BMI 31.37 ± 7.48 kg/m2 , significant improvement in health-related quality of life (HRQOL), PaCO2, PaO2, FEV1, FVC and 6 Minute walk test recorded.

Conclusion: The use of Home NPPV is effective  long-term treatment for individuals with   chronic  respiratory failure by  reducing  patient's symptoms,  improving  health-related quality of life PaCO2, PaO2, FEV1, FVC and  6 Minute walk test.