The Association of Inherited Thrombophilia and Recurrent Pregnancy Loss

Abstract

Recurrent Pregnancy Loss (RPL) is diagnosed when two or more consecutive losses of pregnancy before twenty weeks of gestation occur, RPL represents about 5% of women of reproductive age. About 50%–65% of patients with unexplained RPL (URPL) were diagnosed with thrombophilia. Recent studies have found that inherited and acquired thrombophilia are important causes of URPL.

Thrombophilic disorders are in fact believed to exacerbate the state of hypercoagulability in pregnancy. Factor   V Leiden (FVL) G1691A mutation, prothrombin (PT) G20210A mutation, methylene tetrahydrofolate reductase (MTHFR) C677T, protein c deficiency, antithrombin deficiency   and protein s deficiency are considered major genetic risk factors for thrombophilia. testing for inherited thrombophilia is highly recommended to be included in premarital tests as RPL affects both the physical and psychological states of women.  The RPL patients diagnosed with inherited thrombophilia and who were given LMWH (low molecular weight-heparin) with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those patients with unexplained RPL.