Identifying the Mode of Action of Lemon Grass (Cymbopogon Citratus) against Gastric Cancer Associated with Helicobacter Pylori Infection

Abstract

Purpose: Gastric cancer can be produced by environmental factors (radiation exposure, Smocking, H. Pylori infection) and also genetic factors. Lemongrass (Cymbopogon citratus) has long been a therapeutic and medicinal plant, used for its many beneficial properties. It has been used in various studies to treat stomach cancer.

Methods: The identification of activity, therapeutic potential and screening of numerous target molecules of Cymbopogon citratus related to stomach cancer are studied with its methodical literature analysis. Shiny GO was used for Gene Ontology (GO) enrichment analysis and is designed with multiple functions. (1) gene signatures and enrichment results of graphical visualization, (2) a large annotation database from GO.

Results: A literature review revealed that Cymbopogon citratus had 322 potential targets and 5 relative targets, 4 components, we also examined the relevance of these potential targets to gastric cancer therapy.

Conclusions The network pharmacology analysis revealed multiple biological pathways and target protein interactions which gave evidence through this research that Cymbopogon citratus had potential for the cure of gastric cancer.