Mirtazapine Combined with Paroxetine Can Improve Sleep Quality and Inflammatory Factor Levels in Patients with Postpartum Depression

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Xiaohong Wang et al.


Objective: To determine the effect of a combination of mirtazapine and paroxetine on postpartum depression.

Methods: Totally, 103 patients with postpartum depression admitted to our hospital from January 2017 to March 2019 were enrolled in this study and randomly assigned to Groups A and B. Patients in Group A (n = 49) were treated with paroxetine, while those in Group B (n = 54) were treated with mirtazapine, in addition to paroxetine. The sleep quality, treatment outcome, and inflammatory factors in the two groups were evaluated after treatment.

Results: Group B patients experienced milder depression and better sleep quality and showed lower levels of inflammatory factors than Group A patients (all p < 0.05).

Conclusion: Mirtazapine combined with paroxetine can effectively improve the sleep quality of patients with postpartum depression and lower the levels of inflammatory factors.

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