Prophylactic Effects of Syzygium aromaticum L. and Cynara Cardunculus L. Extracts against d 7,12-dimethylbenz(a)anthracene (DMBA)-Induced Colorectal Cancer in Male Albino Rats

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Khalifa El-Dawy et. al


Colorectal cancer is the third most familiar cancer worldwide. In recent years, colorectal cancer incidence and mortality have increased dramatically in a number of emerging countries. Spices and flavoring plants, are gaining a lot of interest as a potential source of cancer-fighting substances these days. Clove is a spice and food flavour made from the sun-dried unopened flower bud of the plant Syzygium aromaticum L. The Cynara cardunculus L. has evidenced also as anticancer protective compounds on different types of cancer. This study aimed to evaluate the protective potential impact of acetonic extract of clove and ethanolic extract of Cynara cardunculus L. in a rat model with induced d 7,12-dimethylbenz(a)anthracene (DMBA) for 3 months. Our results demonstrated that Cynara cardunculus & Syzygium aromaticum extract induced apoptosis via activation of P53 and caspase-3 in addition to a down regulation of Bcl-2. Our results also showed that the two extracts have a significant inhibitory role on NF-κB and IL-1 β levels. Finally, this study suggested that using clove and Cynara cardunculus extracts may represent a protective antitumor compound against induced DMBA in rats.

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