Antimicrobial Activity of Rhizome of Christella dentata. (forsk.) Brownsey & Jermy Against Selected Microorganisms

Abstract

Men have boundless exposure to several microorganisms, which may cause different infections. These pathogenic organisms can develop resistance due to various reasons. Resistances to antibiotics are a big issue globally because antibiotic resistance treatment effects are reduced, resulting in increased morbidity and mortality worldwide. The need is to reduce the resistance and to develop a novel antimicrobial agent in a natural way. The present study aims to evaluate Chloroform's antifungal and antibacterial activity, ethyl acetate, PBHM, and deionized water extract of Christella dentation: one gram-positive, four gram-negative, and one gram-negative fungal strain. The antimicrobial activity of C.dentata was tested by using the ager well diffusion method. The results showed that the plant exhibited antimicrobial activity in the chloroform and ethyl acetate extract. The chloroform and ethyl acetate showed a maximum level of antimicrobial activity, moderate level of inhibition displayed by PBHM and the lowest level of inhibition showed by deionized water extract. Most sensitive organism was Pseudomonas, Candida albicans and S.aureus. The study confirmed that all extracts showed different antimicrobial activity against tested organisms. The differentiating in the activity of these extracts could serve for the formulation of novel antimicrobial agents in future.