Effect of Propofol and Dexmedetomidine on Pulmonary Injury in Patients with Acute Respiratory Distress Syndrome during Mechanical Ventilation

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Wei Liu, Wei Xu

Abstract

This research intended to explore the role of propofol and dexmedetomidine on pulmonary injury in patients with acute respiratory distress syndrome (ARDS) during mechanical ventilation.Methods: A total of 150 ARDS patients undergoing mechanical ventilation in our hospital from January 2017 to May 2019 were randomly grouped into dexmedetomidine group (n=50), propofol group (n=50) and joint group (n=50). The changes of heart rate, systolic blood pressure, diastolic blood pressure in the three groups were compared. Elisa was applied to test the changes of inflammatory factors interleukin -6 (IL-6) and tumor necrosis factor-α (TNF-α) on the first, second and third days after mechanical ventilation. The pulmonary injury score before sedation and after sedation for 2 days (Table 2) was tested. Secondary outcome measures: the incidence of adverse reactions after anesthesia was observed.Results:After sedation, the mean artery pressure and heart rate of the three groups were significantly lower than those before sedation (P < 0.05). After sedation, the expressions of IL-6 and TNF-α in joint group were significantly lower than those in propofol and dexmedetomidine group (P < 0.05). Two-day pulmonary injury scores of the three groups showed that different sedation schemes had positive effects on improving pulmonary injury scores (P < 0.05), and the expressions of IL-6 and TNF-α declined with the decline of pulmonary injury scores. The incidence of adverse reactions in joint group was significantly higher than that in propofol group and dexmedetomidine group (P < 0.05).Conclusion: Propofol and dexmedetomidine can effectively improve the effect of pulmonary injury in ARDS patients during mechanical ventilation, and slow down the occurrence of inflammatory reaction, which is an effective scheme of sedation in clinical mechanical ventilation.

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