Effect of Combining Clopidogrel Bisulfate with Alteplase on Coagulation Function, Neurological Function and Daily Living Ability of Patients with Coronary Heart Disease

Abstract

To explore the effect of combining clopidogrel bisulfate with alteplase on coagulation function, neurological function and daily living ability of patients with coronary heart disease (CHD). Methods. The clinical data of 90 CHD patients treated in our hospital from January 2019 to January 2021 were retrospectively analyzed, and the patients were divided into the control group and the study group according to the treatment method, with 45 cases each. The patients in the control group accepted the alteplase thrombolysis treatment, and on this basis, the patients in the study group received the clopidogrel bisulfate treatment, so as to analyze the clinical efficacy of both groups after treatment. Results. No statistical differences were observed in the general information between the two groups (P>0.05); the overall effective rate of treatment was significantly higher in the study group than in the control group (P<0.05); after treatment, various coagulation function indicators in both groups were improved, and PT and APTT were obviously better in the study group than in the control group (P<0.05); after treatment, the NIHSS scores of patients in both groups decreased, and the reduction of the study group was significantly greater than that of the control group (P<0.05); after treatment, the Barthel indexes of patients in both groups increased, and the increment of the study group was significantly greater than that of the control group (P<0.05); during treatment, no controllable serious adverse drug reactions occurred in patients of both groups, and the adverse effects were less severe with a low overall incidence and not significantly different between the two groups (P>0.05). Conclusion. Combining clopidogrel bisulfate with alteplase can effectively improve the coagulation function in CHD patients, is conducive to promoting the clinical efficacy, and works well in highly effective anti-thrombosis and improvement of patients’ neurological function and daily living ability.