Effect of Vitamin B12-conjugated Nanocomposite on Drug-resistant Gastric Cancer Cells

Abstract

Sericin nanomicelles (Sericin-PBLG) have the properties of efficiently and stably encapsulating hydrophobic chemotherapeutics in aqueous solution. The vitamin B12 (VB12) modified amphiphilic chitosan derivative can improve the delivery effect of oral drugs and has a targeting function. In this study, a new type of sericin nanomedicine (VB12-sericin-PBLG-PTX) loaded with paclitaxel was successfully synthesized. The particle size of VB12-sericin-PBLG-PTX nanomicelles is 121.5 ±1.6 nm. The nanomicelles can reduce the activity of gastric carcinoma cells and gastric carcinoma drug-resistant cells, and increase the apoptosis rate of gastric carcinoma cells and gastric carcinoma drug-resistant cells, and achieve a good anti-tumor effect.