The Comparison of the Effect of Carboprost Suppository Combined with Romethamine and Carboprost Suppository Combined with Oxytocin in the Prevention of Hemorrhage after Cesarean Section

Abstract

The postpartum hemorrhage increases with the increasing use of cesarean section, one of the common methods of delivery. In order to improve the postoperative safety of women with cesarean section, an effective strategy to prevent bleeding after cesarean section is extremely important. This study compares the preventive effects of carboprost with carboprost tromethamine and carboprost with oxytocin on postpartum hemorrhage of cesarean section, which will provide reference for clinical effective prevention of bleeding after cesarean section.A prospective analysis was performed on 349 cases of cesarean section puerperants. According to the treatment method, they were divided into two groups: carboprost suppository combined with oxytocin group (control group) and carboprost suppository combined with romethamine group (study group). The general data, hemodynamic parameters [heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and blood oxygen saturation(SpO2)], incidence of adverse reactions, bleeding, uterine recovery and drug efficacy of the patients were compared. There were no differences in hemodynamic indexes between the two groups before medication (P> 0.050). After medication, the HR, SBP, and DBP of the study group were lower than those of the control group, and SpO2 of the study group was higher than that of the control group (P <0.001). The HR and SpO2 of the two groups after medication were higher than those before medication, while the SBP and DBP were lower than those before medication (P <0.050). The total postoperative bleeding volume in the study group was lower than that in the control group (P <0.05); the postoperative bleeding rate in the study group was lower than that in the control group (P <0.05). The uterine return in the study group was better than that in the control group (P <0.05).The total effective rate of the control group was higher than that of the control group (P<0.05). The combination of carboprost suppository and romethamine can better prevent the bleeding after cesarean section, and it is worth popularizing and developing.