Effect of Antiplatelet Therapy Combining Aspirin with Tirofiban After Percutaneous Coronary Intervention on the Incidence of Re-occlusion of Blood Vessels and Platelet Aggregation Rate in Patients with Acute Myocardial Infarction

Abstract

Objective. To explore the effect of antiplatelet therapy combining aspirin with tirofiban after percutaneous coronary intervention (PCI) on the incidence of re-occlusion of blood vessels and platelet aggregation rate in patients with acute myocardial infarction (AMI). Methods. A total of 104 AMI patients treated in the Department of Cardiovascular Medicine of our hospital from March 2017 to March 2018 were selected for retrospective analysis, and those who met the inclusion criteria were divided into the experimental group (n=52) and the control group (n=52) by sealed envelope randomization. After admission, all patients received the PCI, then the combined therapy of aspirin and tirofiban was given to the patients in the experimental group, and the patients in the control group orally took the clopidogrel. By detecting the values of n-terminal pro-brain natriuretic peptide (NT-proBNP) level, platelet active function indicators, etc. of patients in both groups after treatment, the treatment effect of antiplatelet in AMI patients after PCI with different drugs was analyzed. Results. After treatment, the levels of the maximum platelet aggregation rate (MPAR), CD63, CD62P, MA, NT-proBNP and left ventricular end-diastolic volume (LVEDV) were significantly lower in the experimental group than in the control group (P<0.001), and the R time, K time, CI values, left ventricular ejection fraction (LVEF), the peak velocity of early diastolic wave (peak E)/peak velocity of late diastolic wave (peak A) under mitral valve (E/A) were significantly higher in the experimental group than in the control group (P<0.001), and during follow-up, the incidence rate of re-occlusion of blood vessels was significantly lower in the experimental group than in the control group (P<0.05). Conclusion. The above results indicated that combining aspirin with tirofiban has a better effect than clopidogrel in the antiplatelet therapy for AMI patients after PCI , and therefore it is recommended.