Clinical Efficacy and Safety Analysis on Targeted Nursing Intervention Combined with Drug Therapy of Aspirin and Clopidogrel in the Treatment of Ischemic Stroke

Abstract

 Objective. The purpose of the study was to investigate the clinical efficacy and safety of targeted nursing intervention combined with drug therapy of aspirin and clopidogrel in the treatment of ischemic stroke. Methods. A total of 118 ischemic stroke patients admitted to our hospital from January 2018 to January 2020 were selected and divided into control group (n=59) and experimental group (n=59) according to the order of admission, and their clinical data were retrospectively analyzed. Among them, the control group patients were treated with aspirin, while the patients in the experimental group received the drug therapy of aspirin combined with clopidogrel. After that, the indexes related to the clinical efficacy and safety of treatment were compared between the two groups. Results. The total effective rate of treatment in the experimental group was significantly higher than that in the control group; the NIHSS and ADL scores in both groups after treatment were significantly better than those before treatment, and after treatment, the NIHSS and ADL scores in the experimental group were significantly better than those in the control group; the serum hs-CRP levels and platelet aggregation rate of the patients after treatment were significantly lower than those before treatment, and the serum hs-CRP levels and platelet aggregation rate of the patients in the experimental group were lower than those in the control group, and after treatment, the mean hs-CRP levels of the patients in the experimental group were within the normal range, with statistically significant differences; during treatment, there were 2 cases of epistaxis in the control group, and 1 case of epistaxis as well as 2 cases of gingival bleeding in the experimental group, and there were no adverse reactions occurring in patients’ skin and mucosa, digestive tract, brain, etc. Conclusion. Over a short period of time, targeted nursing intervention combined with drug therapy of aspirin and clopidogrel, with obvious clinical efficacy and high safety, can effectively improve serum hs-CRP levels, inhibit platelet aggregation as well as improve prognosis in patients.