Effect of Lidocaine Solid Lipid Nano-particles on Sciatic Nerve Anesthesia Block in Rats

Abstract

This research aimed at exploring the effect of lidocaine solid lipid nano-particles on sciatic nerve anesthesia block in rats. Firstly, we prepared liposomes encapsulated  with lidocaine (nano-lidocaine).Then, we stimulated sciatic nerve of rats injected with narcotic drugs, and evaluated their sensory nerve block and motor nerve block. Finally, we observed their systemic toxic reaction and inflammatory infiltration. We found that compared with rats injected with free lidocaine, the sciatic nerve block time of those injected with nano-lidocaine was longer, and its blocking effect on sensory and motor nerve was stronger than that of those injected with free lidocaine. No systemic toxic reaction was observed in the experimental group. Histological examination manifested that there was mild or moderate inflammatory cell infiltration in the free lidocaine group, while there was no obvious cell infiltration in the nano-lidocaine group. Thus, we believe that lidocaine encapsulated with nano-liposomes has a small particle size, which can produce extra long sciatic nerve block in rats without systemic toxicity and local tissue damage. So, it has satisfactory anesthetic effect and safety.