Predictive Values of Serum Progesterone, Human Chorionic Gonadotropin andCA-125 for Pregnancy Outcomes of Threatened Abortion and Subchorionic Hematoma

Abstract

We aimed to study the predictive values of serum progesterone (P), human chorionic gonadotropin (HCG) and CA-125 for the pregnancy outcomes of threatened abortion complicated with subchorionic hematoma (SCH).

Materials and methods: Sixty women with threatened abortion and SCH in 6-10th gestational week, 60 with threatened abortion onlyand 60 healthy pregnant women were selected as groups A-C respectively. Levels of β-HCG, P, estradiol (E2) and CA-125 in peripheral venous blood were measured by chemiluminescence assay. Serum levels of INF-γ, TNF-α, IL-2, IL-4 and IL-10 were detected by ELISA.

Results: Serumβ-HCG, P, CA-125 and E2 levels of group A were significantly lower than those in group C (P<0.05). Groups A and B had significantly higher INF-γ, TNF-α and IL-2 levels but lower IL-4 and IL-10 ones than those of group C (P<0.05).The hospitalization and vaginal bleeding times of group A were significantly longer than those of groups B and C (P<0.05).The success rate of fetal protection, neonatal body weight and gestational age of groups A and B were significantly lower than those of group C (P<0.05). Serum P, E2 and HCG levels were low in women with threatened abortion and SCH in early pregnancy, but CA-125 level was high, accompanied by increased INF-γ, TNF-α and IL-2 together with decreased IL-4 and IL-10.

Conclusion: The onset and progression of SCH may be related to imbalance between T lymphocyte factors towards Th1 direction.