Effects of Shuwei Decoction on the Distribution of Connexin 43 Protein and the Repair and Regeneration of Interstitial Cells of Cajal in Rats with Functional Dyspepsia

Abstract

Shuwei Decoction itself has many functions, not only good for human body, but also has many biological functions. For functional dyspepsia rats, the distribution of connexin 43 protein and the repair and regeneration of interstitial cells of Cajal(RRICC) have different changes in different treatment methods. The purpose of this paper is to study the effect of Shuwei Decoction on the distribution of connexin 43 protein and the RRICC in rats with functional dyspepsia. In order to prove the specific effect of Shuwei Decoction on rats with functional dyspepsia, 50 rats were selected as the research object, and the size of distribution area of Cx43 protein and the cell regeneration were observed. The speed of birth and repair, the distribution of Cx43 protein and the level of Cx43 protein were detected, and the statistical data were studied. The results show that Shuwei decoction can promote the regeneration and formation of ICC, thus obtaining the structural integrity of ICC, improving the potential intestinal disorder and treating FD. Shuwei decoction has a strong effect on the RRICC, which is the result of the increase of the number of intercellular stem cells, and the speed of cell repair and regeneration is increased by nearly 30%. On the basis of the distribution of Cx43 protein, the distribution area increased by 20% compared with the original basis. Therefore, Shuwei decoction has a great influence on the distribution of connexin 43 proteins and the RRICC in rats with functional dyspepsia.