Correlation Analysis of CPN, Hp, HCMV Pathogenic Microorganism Infection Status and Serum Inflammation Marker Level in Patients with Coronary Heart Disease

Abstract

To investigate the correlation between CPN, Hp, HCMV pathogenic microorganism infection status and serum inflammation marker levels in patients with coronary heart disease. Methods: The subjects of this study were all patients with coronary heart disease who came to our hospital from December 2018 to December 2019. A total of 70 patients were selected as the observation group, and non-coronary heart disease patients who came to our hospital for physical examination at the same time 70 cases were used as a control group to detect the IgG antibodies of CPN, Hp and HCMV microorganisms of the two groups, as well as the serum inflammation markers interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-α. Results: The CPN-IgG single positive rate, Hp-IgG single positive rate, HCMV-IgG single positive rate, double positive rate and triple positive rate in the observation group were 10.0%, 14.3%, 18.6%, 41.4% and 11.4%, respectively. , Are significantly higher than the control group, and the difference between the groups is statistically significant (P<0.05); interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-α in three positive patients are (37.4±8.9) pg/ml, (15.1±3.2) mg/L and (36.2±8.6) ng/L, significantly higher than the levels of serum inflammation markers corresponding to double-positive, single-positive and full-negative patients, the difference is statistically significant Significance (P<0.05); serum inflammatory markers of double-positive patients were significantly higher than those of single-positive patients, the difference was statistically significant (P<0.05); serum inflammatory markers of single-positive patients The level of substance was significantly higher than that of serum inflammation markers corresponding to all negative patients, and the difference was statistically significant (P<0.05). Conclusion: The infection load of CPN, Hp and HCMV pathogenic microorganisms in patients with coronary heart disease is positively correlated with the level of serum inflammation markers, which is closely related to the incidence of coronary heart disease. The mixed infection of three pathogenic microorganisms can enhance the inflammatory response of patients by inducing inflammation The reaction causes the occurrence and development of the disease, and the more complicated the pathogenic microbial infection of the patient, the higher the level of inflammation markers of the patient.