Microscope-Study on the Relationship between Islet Cell Antibody and Cell Function in Children with Diabetes Mellitus

Abstract

The purpose of this study was to investigate the relationship between islet cell antibodies and cell function in children with diabetes mellitus. Objective: To investigate the effects of insulin resistance and B-cell failure on blood glucose levels in children with diabetes, so as to provide theoretical basis for rational choice of hypoglycemic drugs and effective control of blood glucose. Methods: 81 children with diabetes mellitus were tested after eating 80g instant noodles for 0, 30, 60, 120 min of blood glucose and insulin. All cases were divided into group A (FPG < 8.92mmol /L) and group B (FPG≥ 8.89mmol /L) according to the fasting blood glucose (FFG) level. The contribution of cell function and insulin resistance to the blood glucose level was assessed in both groups. Results: The sensitivity of insulin and true insulin in group B was 65.5% and 64% of that in group A. After adjusting the effect of insulin resistance, the cell function in group B was only 1/5-1/7 of that in group A. Insulin swabs and cell function, measured by insulin, contributed half to glucose levels in group A, while cell function contributed eight times as much to glucose levels as insulin resistance in group B. Beta cell secretory function, measured with true insulin, explained 43% of the change in blood glucose in group A, 55% of the change in blood glucose in group B, and insulin sensitivity explained 13% of the change in group A, and 5.9% of the change in group B. Conclusion: Insulin resistance and cell failure were more serious in the group with higher fasting glucose level (≥ 8.89mmol /L), and the hyperglycemia was mainly caused by cell failure, suggesting that the combination of insulin sensitizer and insulin secretory agent was beneficial in the initial treatment.