The Potential Implication of the Noisome Nanoparticle of the Rutin and Quercetin in Modulating the Obesity-Induced Testicular Dysfunction in Male Rats

Abstract

Background: Rutin and quercetin, which are flavonoids found in many fruits and vegetables, have attracted interest due to their ability to improve metabolic syndrome and its related testicular dysfunction. Gaining insight into the mechanisms by which they operate and investigating innovative delivery technologies, such as nanotechnology, may present effective approaches for addressing these health issues. Objective: The purpose of this study was to examine the effectiveness of rutin and quercetin-loaded niosomes in reducing obesity induced-testicular dysfunction in a rat model. Methods, A high-fructose diet was used to induce metabolic syndrome in 90 adult male albino rats over the course of ten weeks. The rats were then divided into six different groups. Numerous treatment plans were given, such as the application of rutin and quercetin-filled niosomes. The assessment was centred on markers of testicular oxidative stress and hypothalamic-pituitary gonadal axis. Results: Comparing the rutin and quercetin-loaded niosomes group to the control and obese groups, the results demonstrated a significant increase in oxidative stress markers and sex hormones. In addition, significant alterations in hypothalamic hormones linked to reproductive control were seen, indicating potential benefits for testicular function restoration. Conclusion, Testicular dysfunction associated with metabolic syndrome appears to be improving with the usage of niosomes enriched with rutin and quercetin. The outcomes highlight the efficiency of niosomal delivery techniques in precisely addressing several pathophysiological pathways linked to obesity-induced testicular failure. This creates fresh opportunities for cutting-edge therapeutic methods to address this illness.