Single Nucleotide Polymorphisms of FCRL3

Abstract

Behçet’s disease is a systemic chronic inflammatory disease that shows repeated periods of symptom activity and inactivity. As a result, the disease involves the physical and psychosocial problems of both the various symptoms of BD and aging. Assessment of the physical and psychosocial problems of patients with BD is, therefore, needed not only from the perspective of BD, but also for problems that occur during life in general. Rheumatic diseases are the leading cause of disability and they impose an enormous economic, social and human burden to society. It has been estimated that 10% of the population suffer from these diseases and they considered among the ten leading causes of total disability in the United States, Canada and Mexico. Therefore, disability is a broad and multidimensional term, encompassing different impairments and restrictions that diseased individuals experience in their everyday lives. For this reason, it can be measured in different ways, using a wide variety of tools. Studies have clearly identified Fc receptor genes as heritable susceptibility factors for autoimmune diseases.  They elaborated in detail the binding of anti-idiotype to both the Fcg receptor on B lymphocytes and the B cell receptor could lead to the down-regulation of antibody secretion. Fc receptor-like genes (FCRLs), also known as Fc receptor homologys and immunoglobulin superfamily receptor translocation associated genes. With similarity in structure and sequence to the Fcg receptor genes (Fc receptor genes superfamily members), FCRLs consist of at least eight genes (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5, FCRL6, FCRLA and FCRLB)