Magnesium Deficiency: An Often Overlooked Contributor to Global Vitamin D Insufficiency

Abstract

Magnesium and vitamin D collaborate closely, influencing numerous cellular functions throughout the body. Their combined action is crucial for the proper operation of various organs, and a shortage of either or both can disrupt metabolic balance with significant consequences. Such deficiency inevitably disturbs fundamental metabolic processes essential for overall well-being. Recent observational studies underscore the notable interplay between magnesium intake and vitamin D levels.

All enzymes involved in vitamin D metabolism appear to rely on magnesium, which serves as a co-factor in enzymatic reactions occurring in the liver and kidneys. It's noteworthy that the activity of vitamin D-binding protein also depends on magnesium. Hence, magnesium insufficiency is a covert factor contributing to overall vitamin D deficiency, yet magnesium supplementation has been shown to effectively address this deficiency. Thus, maintaining adequate magnesium levels is crucial for optimizing the functions and benefits of vitamin D. This review explores the physiological aspects of magnesium, the metabolic pathways of both magnesium and vitamin D, potential metabolic interactions between the two, their clinical significance, and the potential benefits of magnesium supplementation in sustaining optimal vitamin D levels.