Overview of Soluble Klotho in Diabetic Nephropathy Patients

Abstract

Diabetic nephropathy (DN) is a progressive kidney disease caused by angiopathy of capillaries in the kidney glomeruli. it is characterized by nephrotic syndrome and diffuse glomerulosclerosis. It is due to longstanding diabetes mellitus. DN is the leading cause of chronic kidney disease in patients starting renal replacement therapy and is associated with increased cardiovascular mortality. The goals of treatment are to slow the progression of kidney damage and control related complications. Kidney cells are the main source of soluble Klotho, but it can also be shed from ependymal cells of the choroid plexus.The reason why soluble Klotho can target tissues and affect various signaling pathways is unknown because no specific receptor for soluble Klotho has yet been identified. The aim of the article to review the role of the soluble klotho in the management of DN patients.