Possible Effects of Simvastatin on Skeletal Muscles

Abstract

Nearly one-third of American people have hyperlipidemia, or high blood cholesterol, putting them at increased risk for cardiovascular disease. The risks of cardiovascular disease can be reduced with the use of statins, which are lipid-lowering drugs that are both widely prescribed and effective. Among the most prevalent adverse effects of statins are muscular cramps, aches, weakness, and, in extremely rare instances, death due to fast muscle breakdown. These negative effects often manifest themselves during or after intense physical activity. Even though we still don't fully understand how statins influence muscular performance, new studies have pointed to a few common components. Physical therapists are in a prime position to detect statin-related side effects because of their expertise in musculoskeletal and exercise disorders. This perspective article aims to accomplish the following goals: (1) to provide a rundown of statin metabolism and action mechanisms; (2) to talk about how statins affect skeletal muscle function; (3) to describe the symptoms and signs of statin-induced myopathies; (4) to explain the tests used to diagnose these conditions.