Fibrinolysis and Thrombolytic Therapy of Medicinal Plants

Abstract

This study aims to explore the role of herbal medicine as an alternative treatment for cardiovascular diseases. Through an in-depth review of the available literature, 31 medicinal plants from 27 families were identified as having thrombolytic properties. A systematic approach was employed to gather, compare, and analyze the results of multiple previous studies focusing on these plants and their thrombolytic effects. Diverse databases, journals, and academic sources were consulted for comprehensive coverage. The selection of these plants resulted in findings that highlight the presence of bioactive molecules, such as flavonoids, alkaloids, and phenolic compounds, with thrombotic effects. Notable plants, including Plumbago zeylanica, Withania somnifera, and Cyperus rotundus, exhibited significant potential ranging from 60% to 96% in preventing thrombosis formation in blood vessels. This effect was achieved through mechanisms involving thrombosis formation, fibrinolysis, and the thrombolytic agentsfindings of this study provide insights for exploring novel natural substances and the development of new therapeutic agents with enhanced thrombosis management properties. Moreover, these potential alternatives offer the advantage of being potentially more sedative in nature compared to conventional treatments.