Brief Overview about Ovarian Cancer

Abstract

Ovarian cancer is a lethal gynaecologic malignancy as more than 70% of women present with advanced-stage disease. The contributing factors were postulated to be excessive gonadotropin and androgen stimulation of the ovary. In the pathogenesis of ovarian cancer, exposure of the ovaries to pelvic pollutants and carcinogens may play a role. Numerous threats and protective factors are recognized in epidemiological and molecular-genetic studies. Ovarian cancer is the second most common gynecologic malignancy in resource-rich countries and the third most common gynecologic malignancy in resource-limited countries (cervical cancer is the most common). Ovarian cancer is the second most common gynecologic malignancy and the most common cause of gynecologic cancer death in the United States.