Study on the Value of miR6503-5p Combined with PGR in the Diagnosis of Early Gastric Cancer

Abstract

Objective To investigate the value of serum miRNA 6503-5p (miR6503-5p) combined with pepsinogen ratio (PGR) in the diagnosis of early gastric cancer. Methods: 94 patients (gastric cancer group) with gastric cancer confirmed by pathological examination and 90 patients with chronic atrophic gastritis collected by Department of Pathology in our hospital were selected as the control group, the serum levels of pepsinogen (PG I, PG II) and miR6503-5p were measured in the two groups, and the value of the two indexes in the diagnosis of gastric cancer was analyzed by ROC. Results: The serum levels of miR6503-5p in gastric cancer group were significantly higher than those in control group (P<0.05), the serum levels of PG I and PGR in gastric cancer group were significantly lower than those in control group (P<0.05), the serum levels of miR6503-5p in stage II gastric cancer group were significantly higher than those in stage I patients with statistically significant difference (P<0.05), and the serum levels of PG I and PGR in stage II gastric cancer group were significantly lower than those in stage I patients with statistically significant difference (P<0.05). The serum levels of PG I, PG II and PGR in the patients with highly and moderately differentiated gastric cancer were not significantly different from those in the patients with poorly and undifferentiated gastric cancer, with no statistically significant different (P>0.05); the serum levels of miR6503-5p in the patients with highly and moderately differentiated gastric cancer were significantly lower than those in the patients with poorly and undifferentiated gastric cancer, with statistically significant difference (P<0.05); the sensitivity of miR6503-5p in diagnosing gastric cancer was 81.33%, the specificity was 71.09%, the area under the ROC curve was 0.767; the sensitivity of PGR in diagnosing gastric cancer was 85.81%, the specificity was 78.40%, and the area under the ROC curve was 0.827. The sensitivity of serum miR6503-5p combined with PGR was 96.40%, the specificity was 85.44%, and the area under the ROC curve was 0.920. Conclusion The miR 6503-5p combined with PGR has high sensitivity and specificity in the diagnosis of gastric cancer and is worthy of clinical application in the screening of patients with early gastric cancer.