A Brief Insight about Obestatin possible relation with Diabetes Complications

Abstract

Obestatin is a hormone linked to the regulation of appetite in humans reducing food intake, body weight gain, gastric emptying and suppression of intestinal motility and it could be a useful marker of the nutritional status reflecting adiposity and insulin resistance.     Obestatin positive effects on glucose and lipid metabolism candidates this peptide as a potential therapeutic tool in pathological conditions such as insulin resistance  and diabetes. Studies in humans have shown that blood obestatin levels are significantly lower in obese subjects and correlate negatively with BMI, insulin, glucose and the HOMA IR. At present, the causative role of obestatin in this complex process is unknown. Although it is tempting to speculate about the potential role of obestatin in pathologic retinal angiogenesis, further results are needed. A worrisome and fragmental clinical finding is that obese patients may develop diabetic retinopathy long before the clinical manifestation of diabetes shows up. Whether this may be explained by change in obestatin level is an open question. The use of obestatin peptide as a regenerative agent for traumatic peripheral nerve damage offers a novel approach to address .Beyond its established role in myogenesis, obestatin singularly enhance both the speed and extent of recovery of motor behavior after crush injury to the sciatic nerve, as analyzed by sciatic functional test. These benfits were associated with regulation of the SC plasticity to direct the differentiation, axonal regrowth, and remyelination.