Efficacy of mesenchymal stem celltherapy in the management of osteoarthritis: a randomized controlled trial

Abstract

Objective

To assess the efficacy of mesenchymal stem cell therapy in the management of osteoarthritis.

Methods

In this study, 45 participants who had obvious symptoms of osteoarthritis were randomly selected and placed in three groups such as control group, single-dose, and double-dose injection therapy groups. Each group consists of 15 participants. Two groups of participants received intra-articular mesenchymal stem cell therapy consisting of either a single or double doseof injection therapies whereas the control group has been treated through a conservative method.

Results

The results of the study revealed that the participants did not experience any severe adverse consequences. Although the participants who received mesenchymal stem cell therapy were placed in single & double dose injection therapy groups experiencedsignificant pain but functional improvement was observed after twelve months of follow-up.

Conclusion

The study has concluded that mesenchymal stem cell therapy is one of the most effective treatments for osteoarthritis and further prevents the progression of the disease.