Comparison of Outcome and Complications of Myocardial Infarction with and without Streptokinase Therapy
Main Article Content
Abstract
Background
Myocardial infarction is a life-threatening condition which needs to treat on emergency basis. Percutaneous coronary angioplasty is the treatment of choice but if the situation is not favorable then fibrinolysis is the best option for myocardial infarction. Streptokinase is the most commonly used fibrinolytic agent worldwide. The aim of the current study was to compare the outcome and complications of myocardial infarction with and without streptokinase therapy in a tertiary care hospital of Karachi
Methods
A descriptive cross-sectional study was conducted in National Institute of Cardiovascular diseases (NICVD), Karachi from May to October 2021. Study participants were divided into two groups; Group-I with streptokinase therapy and Group-II without streptokinase therapy. A self-designed proforma was used. Laboratory investigations carried out were complete blood count, fasting blood sugar, CK-MB level, serum urea, creatinine, lipid profile, chest x-ray, ECG’s and echocardiography. The complications with and without streptokinase therapy and mortality rate was also noted on proforma. Data was analyzed by using Statistical Package for Social Science (SPSS) version-20.
Results
The mean age of the study participants was 49.5±8.7 years. Majority of study participants were male (76.4%) and were smoker (40.2%). The most common co-morbidity among study participant was hypertension (79%) followed by diabetes (38.6%). About 32.1% of the patients were having family history of ischemic heart disease. The most common complication after streptokinase therapy was hypotension (32.7%) while left ventricular failure was most common without streptokinase therapy. Mortality rate was lower with streptokinase therapy (8.6%) as compared to without streptokinase therapy (40.6%), reporting strong association with significant p-value.
Conclusion
It can be concluded that Streptokinase is a best option as a reperfusion therapy in the patients of myocardial infarction as it lowers the mortality rate and the post MI complications.