Effect of Midazolam on Decreasing the Incidence of Adverse Events Occurring During Bronchoscopy Procedure.

Abstract

Background: Bronchoscopy involves the examination of patient airways by advancing a bronchoscope into the lungs. This procedure is essential for diagnosing and treating respiratory disorders but comes with risks such as hypoxia and arrhythmias. Effective sedation techniques are necessary to mitigate these risks. This study assesses the impact of Midazolam on minimizing adverse events during bronchoscopy.

Objectives: The aim is to evaluate the frequency of complications before and after IV Midazolam in patients who have undergone bronchoscopy. The secondary outcomes are the evaluation of the Midazolam’s systemic tolerability and safety in these patients, the rate of coughing and readiness to perform the procedure again.

Study Design: A cross-sectional study

Duration and place of study conducted in the Department of Pulmonology MTI/LRH from January 2021 to July 2021.

Methods

102 patients were enrolled in this cross-sectional study performed at MTI/LRH. Patients were randomly divided into two groups: Of the patients, 51 patients received Midazolam while 51 patients did not receive any form of sedation. The participants included 50% males and the mean age of the participants was 45 years (SD=12). Comparisons of side effects profiles and the incidences of adverse events were made between the two groups.

Results

The overall complication rate was 10% in the Midazolam group while in the no-sedation group it was 30%. Hypoxia reduced from 15% in the no-sedation group to 5% in the Midazolam group. The occurrence of arrhythmias was 3% in the Midazolam group compared to 10% in the no-sedation group. The patients who underwent the procedure with the help of Midazolam also stated that they had significantly less coughing and were willing to repeat the procedure. Moreover, patients in the Midazolam group were found to have anterograde amnesia for the events that took place during the procedure and the subsequent adverse effects.

Conclusion

Midazolam is useful in decreasing the incidence of complications during bronchoscopy, improving the quality of care and comfort of the patient, and has an amnesic action that benefits the patient. It is highly advised for use in case of possible complications during the procedure.