Fluid Therapy and Pulse Pressure Variation in Renal Transplantation

Abstract

Optimal fluid therapy is considered as very crucial to decrease delayed graft function after renal transplantation. The intraoperative period of renal transplantation is divided into two phases. The first phase is the one prior to the reperfusion and the second is after reperfusion of the graft. Prior to reperfusion, physicians should not consider the patients as hypervolemic as they are usually adequately dialyzed. The role of fluid therapy in these patients is very critical, hypovolemia might lead to brain hypoperfusion and over-transfusion might lead increased intracranial tension. All these factors make fluid management in these procedures complex and challenging. Evidence on the optimum protocol for intraoperative fluid management in is Goal-directed therapy (GDT) in the operating room is a term used to describe the use of cardiac output or similar parameters to guide intravenous fluid and inotropic therapy.