ST-Elevation Myocardial Infarction (STEMI) In Elderly with Biomarkers Roles In Contrast Induced Nephropathy

Abstract

Background: Contrast-induced nephropathy (CIN) is associated with an increased risk of major adverse cardiovascular events (MACE), and the association between CIN and oxidative mechanisms is well documented. Several novel renal biomarkers have been proposed to predict early CIN, like kidney injury marker 1 (KIM-1) and cyt C.  KIM-1 is a type-1 transmembrane protein, expressed according to the injury in the proximal tubule of the apical membrane.  Many studies show that KIM-1 is a sensitive and specific marker of kidney injury as well as a predictor of prognosis especially in acute kidney injury